Product Description

LGR4 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS72418-50, BS72418-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9BXB1

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB IF

All Applications: WB 1:1000 - 1:3000
IF 1:50 - 1:200

Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LGR4 polyclonal antibody detects endogenous levels of LGR4 protein.

Bioworld Molecular Weight: ~ 109 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of extracts of various cell lines, using LGR4 antibody.

Alternative Name: BNMD17; GPR48

Immunogen: Recombinant protein of human LGR4

Conjugate: Unconjugated

Modification: Unmodified