Product Description

LGR5 (2G11) Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB8016-50, MB8016-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors or heptahelical receptors, interact with G proteins (heterotrimeric GTPases) to synthesize intracellμlar second messengers, such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. LGR5 (leucine-rich repeat-containing G protein-coupled receptor 5), also known as GPR49 or GPR67, is a 907 amino acid mμlti-pass membrane protein that contains 17 leucine-rich repeats and belongs to the G protein-coupled receptor family. Expressed in placenta, skeletal muscle and spinal cord, LGR5 functions as an orphan receptor that is thought to play an important role in embryonic growth control and cellμlar differentiation. Overexpression of LGR5 is associated with increased tumor susceptibility and malignant transformation, implicating LGR5 as a potent tumor-inducing protein.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: FC, ELISA

Alternate Names: Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Purified recombinant fragment of human LGR5 expressed in E. Coli.

Dilution: FC: 1/50-1/100 ELISA: 1/10000

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: LGR5 Monoclonal Antibody detects endogenous levels of LGR5 protein.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O75473

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only