LIMK1 (Phospho-Ser310) Rabbit Polyclonal Antibody - RA36888

LIMK1 (Phospho-Ser310) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36888-50, RA36888-100

Citations, Manuals and MSDS Available upon request.

Background: LIM domain kinase 1 (LIMK1) Homo sapiens There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog

Condition: Liquid in PBS containing 50% glycerol, and 0.204% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 3984

Protein MW (KDa): 80

SWISS: P53667

Source: Rabbit

Research Use Only