LITAF Polyclonal Antibody - BT-AP10930

LITAF Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP10930-20, BT-AP10930-50, BT-AP10930-100

Citations, Manuals and MSDS Available upon request.

Background: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Pagetandapos;s disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.

Research Areas: Epigenetics and nuclear signaling; Signal transduction

Target Protein: LITAF

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Lipopolysaccharide-induced tumor necrosis factor-alpha factor

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q99732; Mouse: Q9JLJ0; Rat: P0C0T0

Synonyms: Lipopolysaccharide-induced tumor necrosis factor-alpha factor;LPS-induced TNF-alpha factor;Small integral membrane protein of lysosome/late endosome;p53-induced gene 7 protein

GeneID: Human: 9516

Research Use Only