Product Description

LKB1 (R425) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1785-50, BS1785-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regμlates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression resμlts in a G1 cell cycle arrest.Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macμles on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regμlating AMPK related kinases as well as AMPK.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Serine/threonine-protein kinase STK11, Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19, STK11, LKB1, PJS

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 396-442 of Human LKB1.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: LKB1 (R425) polyclonal antibody detects endogenous levels of LKB1 protein.

Molecular Weight: ~ 48, 54 kDa

Pathway: Warburg Effect, Translational Contral elF4 and p70 S6 Kinase, Glutamine Metabolism, AMPK Signaling Pathway, MTOR signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15831

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only