Product Description

LMNA Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4444-25, MB4444-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing resμlts in mμltiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscμlar dystrophy, familial partial lipodystrophy, limb girdle muscμlar dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: IF, WB

Alternate Names: CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Fμll length human recombinant protein of human LMNA (NP_733821) produced in HEK293T cell.

Dilution: WB 1:2000

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG2b

Molecular Weight: 74 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P02545

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only