LOX 1 Polyclonal Antibody Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Sizes: 50µl, 100µl Catalogue Numbers: BS65855-50, BS65855-100 Swiss-Prot: Q9XTA8 Host: Rabbit LOX 1 Polyclonal Antibody-BS65855 Storage and Stability: Store at 4°C short term. Aliquot and store at -28°C long term. Avoid freeze-thaw cycles. Reactivity: Human, Mouse, Rat, Cow, Rabbit, Applications: WB, All Applications: WB=1:500-2000 Background: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Purification and Purity: affinity purified by Protein A Specificity: LOX 1 Polyclonal Antibody detects endogenous levels of LOX 1 protein. Bioworld Molecular Weight: ~50 kDa Note: For research use only, not for use in diagnostic procedure. Extra Notes: Primary: Anti- LOX1 at 1/300 dilution, Primary: Anti-LOX 1 at 1/300 dilution Alternative Name: Lectin-type oxidized LDL receptor 1; OLR1; lectin-like low density lipoprotein receptor-1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; LOX-1; BLOX1; Contains: Oxidized low-density lipoprotein receptor 1, soluble form A; Oxidized low-density lipoprotein receptor 1, soluble form B; OLR1_HUMAN. Immunogen: KLH conjugated synthetic peptide derived from rabbit LOX-1:201-273/273 Modification: Unmodified Conjugate: Unconjugated