LOX 1 Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS65855-50, BS65855-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascμlar endothelial cells. OxLDL is a marker of atherosclerosis that induces vascμlar endothelial cell activation and dysfunction, resμlting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellμlar reactive oxygen and a variety of pro-atherogenic cellμlar responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecμle at the vascμlar interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Category: Primary Antibody Reactivity: Human, Mouse, Rat, Cow, Rabbit Host: Rabbit Applications: WB Alternate Names: Lectin-type oxidized LDL receptor 1, OLR1, lectin-like low density lipoprotein receptor-1, Oxidized low-density lipoprotein receptor 1, Ox-LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, LOX-1, BLOX1, Contains: Oxidized low-density lipoprotein receptor 1, soluble form A, Oxidized low-density lipoprotein receptor 1, soluble form B, OLR1_HUMAN. Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH conjugated synthetic peptide derived from rabbit LOX-1:201-273/273 Dilution: WB=1:500-2000 Purification: affinity purified by Protein A Specificity: LOX 1 Polyclonal Antibody detects endogenous levels of LOX 1 protein. Molecular Weight: ~50 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -28°C long term. Avoid freeze-thaw cycles. SwissProt: Q9XTA8 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Research Use Only