Product Description

LOX Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66952-50, MB66952-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: LOX (lysyl oxidase) is a secreted copper-dependent amine oxidase and a member of the lysyl oxidase family . It primarily catalyzes the oxidation of lysine (or hydroxylysine) residues in collagen and elastin to form peptidyl aldehyde derivatives . These modifications are required for further cross-linking of target proteins to enhance ECM (extracellμlar matrix) stiffness. LOX plays critical roles in vascμlar, lung, and skin development, and tissue damage repair . Upregμlation of LOX is associated with various diseases, including cancer progression and tissue fibrosis. Aberrant LOX activity creates a favorable tumor microenvironment to promote tumor metastasis and distal colonization .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Protein-lysine 6-oxidase, Lysyl oxidase

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LOX. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of LOX protein.

Molecular Weight: ~ 47 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P28300

Product: Mouse IgG2b. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only