LOX Monoclonal Antibody-MB66952

LOX Monoclonal Antibody

Catalogue Numbers: MB66952-50, MB66952-100

Sizes: 50µl, 100µl

Product: Mouse IgG2b. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P28300

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: LOX (lysyl oxidase) is a secreted copper-dependent amine oxidase and a member of the lysyl oxidase family . It primarily catalyzes the oxidation of lysine (or hydroxylysine) residues in collagen and elastin to form peptidyl aldehyde derivatives . These modifications are required for further cross-linking of target proteins to enhance ECM (extracellular matrix) stiffness. LOX plays critical roles in vascular, lung, and skin development, and tissue damage repair . Upregulation of LOX is associated with various diseases, including cancer progression and tissue fibrosis. Aberrant LOX activity creates a favorable tumor microenvironment to promote tumor metastasis and distal colonization .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of LOX protein.

Extra Notes: Western blot analysis of LOX expression in MDAMB231 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 47 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Protein-lysine 6-oxidase; Lysyl oxidase

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LOX. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified