LOX Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90804-50, BS90804-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P28300(Human) P28301(Mouse) P16636(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat, Zebrafish
Applications: WB, ICC IHC FC
All Applications: WB:1:500-1:2,000
ICC:1:100-1:500
IHC:1:50-1:100
FC:1:50-1:100
Background: The lysyl oxidase family of extracellular proteins includes LOX and four LOX-like enzymes, which are responsible for the deamination of peptidyl lysine residues of collagens and elastin. They also catalyze inter- and intra-crosslinking reactions. Overexpression of LOX may cause severe fibrotic degeneration due to its high resistance to degradative enzymes. Procollagen C-proteinase activity processes LOX from a precursor protein to a mature form. Activation of LOX occurs in normal developing and adult skin, and alterations in LOX expression and activity are associated with skin aging and senescence. LOX is crucial for development of the cardiovascular and respiratory systems. In addition, LOX plays a role in cancer, wound healing, as well as cell motility, chemotaxis and differentiation.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: LOX polyclonal antibody detects endogenous levels of LOX protein.
Bioworld Molecular Weight: 50 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of LOX on different lysates using anti-LOX antibody at 1/1,000 dilution.
Positive control:
Lane 1: Jurkat
Lane 2: Mouse brain
Lane 3: Human fetal brain, ICC staining LOX in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: LOX, lox, LYOX, LYOX, Lysyl oxidase, MGC105112, Protein lysine 6 oxidase, Protein-lysine 6-oxidase,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified