Product Description

LPHN2 Polyclonal Antibody

Catalogue Numbers: BS60779-50, BS60779-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O95490

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The Latrophilin family of G protein-coupled receptors consists of three members, latrophilin-1, 2 and 3, each of which displays distinct tissue distribution and function. Latrophilin-1, the most characterized member of this family, acts as a receptor for a-latrotoxin, a component of venom from the black widow spider. Binding of a-latrotoxin to latrophilin-1 triggers synaptic vesicle exocytosis via both Ca2+-dependent and -independent mechanisms, resulting in vesicle depletion. Latrophilin-1 is abundant in brain and present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 expression is ubiquitous.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LPHN2 polyclonal antibody detects endogenous levels of LPHN2 protein.

Extra Notes: Western blot (WB) analysis of LPHN2 pAb at 1:500 dilution
Lane1:U-87MG whole cell lysate(40ug)
Lane2:H1792 whole cell lysate(40ug)
Lane3:HepG2 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 220 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Latrophilin-2; Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; Latrophilin homolog 1; Lectomedin-1; LPHN2; KIAA0786; LEC1; LPHH1

Immunogen: A synthetic peptide corresponding to residues in Human LPHN2

Conjugate: Unconjugated

Modification: Unmodified