LRP2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A3612-20, A3612-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR) .
Category: Polyclonal Antibodies
Applications: WB, IF-P, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 522kDa
Observed Molecular Weight: 522kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 4036
SWISS: P98164
Alternate Names: DBS; GP330; LRP-2; LRP2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:200 - 1:1000 IF-P, 1:50 - 1:200 IHC-P, 1:20 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Cell Biology Developmental Biology, Endocrine Metabolism, Lipid Metabolism, Endocrine and metabolic diseases, Obesity, Stem Cells, Cardiovascular, Lipids, Fatty Acids.
NCBI Alias: LRP2
Research Use Only