LRP2 rabbit pAb - ES9778

LRP2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES9778-50, ES9778-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of th

Source: Rabbit

Applications: IHC; IF

Dilution: IHC-p 1:50-300

Reactivity: Human; Rat; Mouse

Immunogen: Synthesized peptide derived from human protein . at AA range: 2890-2970

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 512kD

Human Gene ID: 4036

Human SWISS Prot NO: P98164

Subcellular Location: Apical cell membrane; Single-pass type I membrane protein. Endosome lumen. Membrane, coated pit. Cell projection, dendrite. Cell projection, axon. Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes as a soluble form.

Research Use Only