LRP6 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A6134-20, A6134-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse, Rat
Protein Weight: 180kDa
Observed Molecular Weight: 160kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 4040
SWISS: O75581
Alternate Names: ADCAD2; STHAG7; LRP6
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Translation Control, Regulation of eIF4 and p70 S6 Kinase, Protein phosphorylation, Signal Transduction, mTOR Signaling Pathway, Cell Biology Developmental Biology, Microtubules, Wnt -Catenin Signaling Pathway, ESC Pluripotency and Differentiation, Stem Cells.
NCBI Alias: LRP6
Research Use Only