LRRK1 Polyclonal Antibody - BT-AP05082

LRRK1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP05082-20, BT-AP05082-50, BT-AP05082-100

Citations, Manuals and MSDS Available upon request.

Background: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. LRRK1 (leucine-rich repeat serine/threonine-protein kinase 1), also known as RIPK6, Roco1 or KIAA1790, is a 2038 amino acid cytoplasmic protein that contains one protein kinase domain, four ANK repeats and 11 leucine-rich repeats and belongs to the Ser/Thr protein kinase family. Using magnesium as a cofactor, LRRK1 catalyzes the ATP-dependent phosphorylation of target proteins. The gene encoding LRRK1, which is expressed as four alternatively spliced isoforms, is thought to be involved in the pathogenesis of Parkinson's disease.

Research Areas: Neuroscience

Target Protein: LRRK1

Applications: IHC-p, IF, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: LRRK1 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 227843

UniProt Accession: Human: Q38SD2; Mouse: Q3UHC2

Synonyms: LRRK1; KIAA1790; Leucine-rich repeat serine/threonine-protein kinase 1

GeneID: Human: 79705

Research Use Only