Lupus La Monoclonal Antibody-MB66617

Lupus La Monoclonal Antibody

Catalogue Numbers: MB66617-50, MB66617-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P05455

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: La antigen is recognized by antibodies in patients with autoimmune disorders such as systemic lupus erythematosus and Sjögren's syndrome. La antigen binds to the 5'-noncoding region of poliovirus RNA and is an IRES trans-acting factor. Depletion of La antigen reduces the function of poliovirus IRES in vivo. La antigen, when phosphorylated at Ser366, has been shown to associate with nuclear precursor tRNAs and facilitate their processing. The nonphosphorylated La antigen interacts with the mRNAs that have 5'-terminal oligopyrimidine (5'TOP) motifs to control protein synthesis.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Lupus La protein.

Extra Notes: Western blot analysis of Lupus La expression in MCF7 (A), A549 (B), Jurkat (C), Hela (D) whole cell lysates.

Bioworld Molecular Weight: ~ 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Lupus La protein; La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B

Immunogen: Purified recombinant human La Antigen protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified