LXR alpha Monoclonal Antibody-MB11179

LXR alpha Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11179-50, MB11179-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q13133

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 50 kDa; Observed MW: 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of LXR alpha in Jurkat lysates using LXR alpha antibody., Western blot analysis of LXR alpha in rat Brain lysates using LXR alpha antibody., Immunohistochemistry analysis of paraffin-embedded Human breast cancer using LXR alpha antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: NR1H3; LXRA; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3

Immunogen: A synthetic peptide of human LXR alpha

Conjugate: Unconjugated

Modification: Unmodified