Product Description

Ly-6G/C Rat Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB65861-50, MB65861-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Ly-6 complex is a series of genes found on chromosome 15. These genes code for a number of different proteins that can be used as surface markers. The family members vary in their biologic expression and have been shown to be involved in cell signaling and cell adhesion. The structure of these proteins includes a motif known as the LU domain that has three loops comprised of disμlfide bonds. These bonds are formed by 8 to 10 cysteines that can cause differences in the length of the loops as well as the sequences at each tip. There are 11 known Ly-6 genes on murine chromosome 15 that code for different proteins. These family members, excluding secreted Ly6/Plaur domain containing 1 coded by the Slurp1 gene, are attached to the cell surface by a GPI anchor near the C terminus. The structure of these proteins may play a role in transmembrane interactions, and downstream signaling cascades. Ly-6 proteins have been widely used as differentiation markers on hematopoietic cells. The ability to isolate and express specific Ly-6 antibodies through hybridoma technology has allowed researchers to identify unique proteins. These proteins are expressed on subsets of immune cells at different stages of development, such as T cells, B cells, monocytes, granμlocytes, and macrophages. The HK1.4 clone is widely used to activate T lymphocytes.

Category: Primary Antibody

Reactivity: Mouse

Host: Rat

Applications: IF, FC

Alternate Names: Lymphocyte antigen 6C1, Ly-6C1, Lymphocyte antigen 6G, Ly-6G

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Raised against granμlocytes of mouse origin

Dilution: IF (1/50 - 1/200)

Purification: The monoclonal antibody was affinity-purified from rat antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes mouse Ly-6G/C

Molecular Weight: ~ 14 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P0CW02, P35461

Product: Rat IgG2b kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Research Use Only