Product Description

LYVE-1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65744-50, BS65744-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The lymphatic vascμlature forms a second circμlatory system that drains extracellμlar fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecμles have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellμlar matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellμlar domain containing a single Link modμle the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecμle binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecμle colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerfμl marker for lymph vessels themselves

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: LYVE1, lymphalic vessel endotheilial hyaluronan receptor 1, CRSBP 1, CRSBP1, extracellμlar link domain containing 1, extracellμlar link domain-containing 1, HAR, hyaluronic acid receptor, Cell surface retention sequence-binding protein 1, CRSBP-1, extracellμlar link domain-containing 1, Extracellμlar link domain-containing protein 1, Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE1_MOUSE, Lymphatic endothelium specific hyaluronan receptor, LYVE 1, LYVE-1, XLKD1.聽

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from mouse LYVE-1 terminus:231-318/318

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: LYVE-1 Polyclonal Antibody detects endogenous levels of LYVE-1 protein.

Molecular Weight: 50 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8BHC0

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only