M3K12 Polyclonal Antibody - BT-AP11026

M3K12 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11026-20, BT-AP11026-50, BT-AP11026-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

Research Areas: Signal transduction

Target Protein: MAP3K12

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Mitogen-activated protein kinase kinase kinase 12

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q12852; Mouse: Q60700; Rat: Q63796

Synonyms: Mitogen-activated protein kinase kinase kinase 12;EC 2.7.11.25;Dual leucine zipper bearing kinase;DLK;Leucine-zipper protein kinase;ZPK;MAPK-upstream kinase;MUK;Mixed lineage kinase

GeneID: Human: 7786

Research Use Only