Product Description

mAChR M1 (R336) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2708-50, BS2708-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The muscarinic acetylcholine receptors (mAChR) mediate a variety of cellμlar responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modμlation of potassium channels. The mAChRs transducer signals by coupling to G-proteins, which then modμlate several downstream effector proteins and ion channels. Five mAChR subtypes have been identified, designated M1 to M5. The five receptor subtypes show distinct patterns of tissue distribution, as well as distinct pharmacological and functional properties. The amino acid sequence of each mAChR subtype reflects a structure that is characteristic of G-protein coupled receptors, consisting of seven highly conserved transmembrane segments and a large intracellμlar region unique to each subtype, which constitutes the effector-coupling domain.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: CHRM1
, ACM1
, Muscarinic acetylcholine receptor M1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 311-360 of Human mAChR M1.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: mAChR M1 (R336) polyclonal antibody detects endogenous levels of mAChR M1 protein.

Molecular Weight: ~ 50 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P11229

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only