MADD Polyclonal Antibody-BS67010

MADD Polyclonal Antibody

Catalogue Numbers: BS67010-50, BS67010-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q8WXG6

Host: Rabbit

Reactivity: Human, Rat

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:20937701, PubMed:18559336).Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:20937701, PubMed:18559336).Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity).Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity).Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity).

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of MADD protein.

Extra Notes: Western blot analysis of MADD expression in PC12 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 200 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: DENN; IG20; KIAA0358; MAP kinase-activating death domain protein; Differentially expressed in normal and neoplastic cells; Insulinoma glucagonoma clone 20; Rab3 GDP/GTP exchange factor

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MADD. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified