Product Description

MAGEB2 Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4034-25, MB4034-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cancer/testis antigens (CTAs) are a family of more than 100 proteins whose normal expression is largely restricted to immune privileged germ cells of the testis, ovary, and trophoblast cells of the placenta. Although most normal somatic tissues are void of CTA expression, due to epigenetic silencing of gene expression, their expression is upregμlated in a wide variety of human solid and liquid tumors (1, 2). As such, CTAs have garnered much attention as attractive targets for a variety of immunotherapy-based approaches to selectively attack tumors (3). Melanoma-associated antigen-A4 (MAGE-A4) is a cancer testis antigen that belongs to the type I MAGE family of proteins. MAGE-A4 is often overexpressed and mutated in several types of cancer (4-8). Research shows MAGE-A4 promotes aberrant cell growth by preventing p53-dependent cell cycle arrest and apoptosis in normal oral keratinocytes (9). However, MAGE-A4 was also found to interact with the liver oncoprotein gankyrin, suppressing its tumorigenic activity (10). The diverse roles of MAGE-A4 in tumor development may be dependent upon sub-cellμlar localization (nuclear or cytosolic) and p53 status (6). Due to its upregμlated expression in human tumors and high degree of immunogenicity, MAGE-A4 has received significant attention as an immunotherapy target through the use of vaccines and adoptive cell therapy (11-14).

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Melanoma-associated antigen B2, Cancer/testis antigen 3.2 (CT3.2), DSS-AHC critical interval MAGE superfamily 6 (DAM6), MAGE XP-2 antigen, MAGE-B2 antigen

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Human recombinant protein fragment corresponding to amino acids 1-224 of human MAGEB2 (NP_002355) produced in E.coli.

Dilution: WB 1:2000

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG1

Molecular Weight: ~ 40 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15479

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only