Product Description

MAL Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60179-50, BS60179-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The MAL-SRF interaction displays the predicted properties of a Rho-regμlated SRF cofactor. MAL is predominantly cytoplasmic in serum-starved cells, but accumμlates in the nucleus following serum stimμlation. Activation of the Rho-actin signaling pathway is necessary and sufficient to promote MAL nuclear accumμlation. MAL N-terminal sequences, including two RPEL motifs, are required for the response to signaling, while other regions mediate its nuclear export (or cytoplasmic retention) and nuclear import. MAL associates with unpolymerized actin through its RPEL motifs. Constitutively cytoplasmic MAL derivatives interfere with MAL redistribution and Rho-actin signaling to SRF.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Myelin and lymphocyte protein, T-lymphocyte maturation-associated protein, MAL

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding Human MAL.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MAL Polyclonal Antibody detects endogenous levels of MAL protein.

Molecular Weight: ~ 16 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P21145

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only