Product Description

MAML2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA33228-50, RA33228-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: mastermind like transcriptional coactivator 2 (MAML2) Homo sapiens The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-riand contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the p

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 127

Protein Molecular Weight (kDa): 127

Storage: -20°C/1 year

Human Gene ID: 84441

Human SwissProt Number: Q8IZL2

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only