Product Description

MAP2K2 (MEK2 ) Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4141-25, MB4141-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: FC, IHC, WB

Alternate Names: CFC4, MAPKK2, MEK2, MKK2, PRKMK2

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Fμll-length protein expressed in 293T cell transfected with human MAP2K2 expression vector

Dilution: WB 1:2000, IHC 1:150, FLOW 1:100

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG1

Molecular Weight: 44.4 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P36507

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only