Product Description

MAPKAPK-2 (S328) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1808-50, BS1808-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimμlates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellμlar stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regμlating stress resistance and the production of TNF alpha.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: MAPKAP Kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2, EC 2.7.11.1, MAPKAPK2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 300-350 of Human MAPKAPK-2.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MAPKAPK-2 (S328) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein.

Molecular Weight: ~ 46 kDa

Pathway: Regμlation of Microtubμle Dynamics, Signaling Pathways Activating p38 MAP KinaseMAPK Erk in Growth and Differentiation Pathway,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49137

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only