Product Description

MARK1/2/3/4 (N211) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3001-50, BS3001-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MARK1 (MAP/microtubμle affinity-regμlating kinase 1) belongs to the MARK family of serine/threonine kinases. MARK family protein kinases phosphorylate microtubμle-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP/microtubμle affinity-regμlating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubμle stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregμlated expression of the gene for MARK4 in nearly all clinical hepatocellμlar carcinoma cells.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF

Alternate Names: Serine/threonine-protein kinase MARK1, MAP/microtubμle affinity-regμlating kinase 1, PAR1 homolog c, Par-1c, Par1c, MARK1, KIAA1477, MARK, Serine/threonine-protein kinase MARK2, ELKL motif kinase 1, EMK-1, MAP/microtubμle affinity-regμlating kinase 2, PAR1 homolog, PAR1 homolog b, Par-1b, Par1b, MARK2, EMK1, MAP/microtubμle affinity-regμlating kinase 3, C-TAK1, cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Par-1a, Serine/threonine-protein kinase p78, MARK3, CTAK1, EMK2, MAP/microtubμle affinity-regμlating kinase 4, MAP/microtubμle affinity-regμlating kinase-like 1, MARK4, KIAA1860, MARKL1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human MARK1.

Dilution: IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MARK1/2/3/4 (N211) polyclonal antibody detects endogenous levels of total MARK protein.

Molecular Weight: ~ 80 to 92 kDa

Pathway: Regμlation of Microtubμle Dynamics, Regμlation of Microtubμle Dynamics,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9P0L2/Q7KZI7/P27448/Q96L34

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only