Maspin Polyclonal Antibody-BS6215

Maspin Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Sizes: 50µl, 100µl

Catalogue Numbers: BS6215-50, BS6215-100

Swiss-Prot: P36952

Host: Rabbit

Maspin Polyclonal Antibody-BS6215

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse

Applications: WB, IHC

All Applications: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Background: Maspin is structurally a serine protease inhibitor (serpin) that was initially isolated from normal human mammary epithelial cells. Serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases. Serpins control activated proteinases and several are involved in the regulation of cell death. Maspin is found in the extracellular matrix and at the plasma membrane. Maspin has been shown to act at the cell surface to block cell motility and inhibit invasion of breast and prostate cancer cells. Maspin is present in normal mammary epithelial cells but is absent in many tumor cell lines, yet no major structural alterations of the Maspin gene have been identified in tumor cells. Similarly, Maspin is expressed in normal prostate cells and downregulated or absent in prostate tumor cells..

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Maspin polyclonal antibody detects endogenous levels of Maspin protein.

Bioworld Molecular Weight: ~ 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: WesternBlot (WB) analysis of Maspin polyclonal antibody in extracts from HT-29 and NIH3T3 cells., Immunohistochemistry (IHC) analysis of Maspin pAb in paraffin-embedded Human Colon tissue.

Alternative Name: Serpin B5; Maspin; Peptidase inhibitor 5; PI-5; SERPINB5; PI5

Immunogen: Recombinant full length Human Maspin.

Modification: Unmodified

Conjugate: Unconjugated