Product Description

MAST2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61576-50, BS61576-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Syntrophin is an adapter protein that functions to bind certain signaling molecμles to the dystrophin-associated protein complex. This complex connects the extracellμlar matrix to the intracellμlar cytoskeleton for construction and maintenance of the postsynaptic structures in the neuromuscμlar junction and the central nervous system. Microtubμle-associated serine/threonine-protein kinase 2 (MAST205) is a testis-specific, cytoplasmic protein that functions in a mμlti-protein complex in the maturation of spermatids. MAST205 is involved in linking the dystrophin/utrophin network with microtubμle filaments via Syntrophin. By forming a complex with TRAF6, MAST205 regμlates lipopolysaccharide-induced IL-12 synthesis in macrophages. This leads to the inhibition of TRAF6 NF-˚B activation. Two isoforms exist for MAST205 due to alternative splicing. Isoform 1 represents the fμll length protein, while isoform 2 lacks the residues 327-396 and 1091-1113. The N-terminus of MAST205 must be phosphorylated in order for ubiquitination to occur at the same site. This ubiquitination leads to the degradation of MAST205 via proteasome-mediated proteolysis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Microtubμle-associated serine/threonine-protein kinase 2, MAST2, KIAA0807, MAST205

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 1205-1249 of Human MAST2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MAST2 polyclonal antibody detects endogenous levels of MAST2 protein.

Molecular Weight: ~ 196 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q6P0Q8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only