Product Description

Matrin 3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90827-50, BS90827-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P43243(Human) Q8K310(Mouse) P43244(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC, IF, IHC, FC

All Applications: WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Matrin-3 is a nuclear matrix protein containing one matrin-type zinc finger and two RRM (RNA recognition motif) domains. Matrin-3 plays a role in transcription and may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the PSF-p54/NRB heteromer, Matrin-3 may play a role in the nuclear retention of defective RNAs. As the main substrate for PKA-mediated phosphorylation, Matrin-3 may serve as a rapid way of transferring information from synapses containing NMDA receptors to neuronal nuclei under physiological conditions. Also, the phosphorylation of Matrin-3 may contribute to neuronal death under pathological conditions. It is likely that Matrin-3 activity is regulated by calcium dependent interaction with CaM I and also by caspase induced cleavage.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Matrin 3 polyclonal antibody detects endogenous levels of Matrin 3 protein.

Bioworld Molecular Weight: 95 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Matrin 3 on different lysates using anti-Matrin 3 antibody at 1/1,000 dilution.
Positive control:
Lane 1: Daudi
Lane 2: Mouse brain tissue, ICC staining Matrin 3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: MATR3, ALS21, KIAA0723, Matr3, MATR3, Matrin-3, Matrin3, MPD2, VCPDM, Vocal cord and pharyngeal weakness with distal myopathy,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified