MBD2 rabbit pAb - ES15022

MBD2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES15022-50, ES15022-100

Citations, Manuals and MSDS Available upon request.

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human MBD2 AA range: 110-160

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 8932

Human SWISS Prot NO: Q9UBB5

Subcellular Location: Nucleus. Nuclear, in discrete foci. Detected at replication foci in late S phase.

Research Use Only