MBD3 rabbit pAb - ES2756

MBD3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2756-50, ES2756-100

Citations, Manuals and MSDS Available upon request.

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],

Alternate Name: MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human MBD3. AA range:221-270

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 33kD

Human Gene ID: 53615

Human SWISS Prot NO: O95983

Subcellular Location: Nucleus. Chromosome. Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.

Research Use Only