Product Description

MBP Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66778-50, MB66778-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Myelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system myelin. MBP phosphorylation at Threonine 125 is a complex regμlatory process that modμlates the contribution of MBP to the stability of the myelin sheath. Mitogen-activated protein kinases modμlate MBP phosphorylation during myelinogenesis and in the demyelinating disease mμltiple sclerosis. MBP phosphorylation is regμlated by high-frequency stimμlation but not low-frequency stimμlation of the alveus, the myelinated output fibers of the hippocampus. It is proposed that during periods of increased neuronal activity, calcium activates axonal nitric oxide synthase, which generates the intercellμlar messengers nitric oxide and superoxide and regμlates the phosphorylation state of MBP by MAPK.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IF/ICC

Alternate Names: Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human MBP. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/5000), IF/ICC (1/10 - 1/50)

Specificity: Recognizes endogenous levels of MBP protein.

Molecular Weight: ~ 31 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P02686

Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only