Product Description

MC5-R (E308) Polyclonal Antibody

Catalogue Numbers:BS2812-50, BS2812-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P33032

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The melanocortin family comprises the α-, β- and γ-melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these hormones are seven-transmembrane, G protein-coupled proteins that activate adenylyl cyclase. Five melanocortin receptors have been cloned and shown to exhibit different affinities and patterns of expression. MC1-R (MSH-R) is expressed in melanocytes and corticoadrenal tissue. MC2-R is the ACTH receptor and is expressed primarily in the adrenal cortex. MC3-R has been found in specific regions of the brain and is also expressed in placenta and gut. MC4-R is expressed primarily in brain, while MC5-R is expressed at low levels in most tissues.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~ 40 kDa

Specificity: MC5-R (E308) polyclonal antibody detects endogenous levels of MC5-R protein.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: Melanocortin receptor 5; MC5-R; MC-2; MC5R

Immunogen: Synthetic peptide, corresponding to amino acids C-terminus of Human MC5-R.

Conjugate: Unconjugated

Modification: Unmodified