MCM2 (Phospho-Ser139) Rabbit Polyclonal Antibody - BT-AP03565

MCM2 (Phospho-Ser139) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP03565-20, BT-AP03565-50, BT-AP03565-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4| 6| and 7| and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated| and thus regulated by| protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found| but the full-length nature of some variants has not been defined.

Research Areas: Epigenetics and nuclear signaling

Target Protein: MCM2

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: MCM2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P49736; Mouse: P97310

Synonyms: MCM2;Ser139; DNA replication licensing factor MCM2; EC 3.6.4.12; Minichromosome maintenance protein 2 homolog; Nuclear protein BM28

GeneID: Human: 4171; Mouse: 17216

Research Use Only