MCM4 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-15771-60, E-AB-15771-120, E-AB-15771-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: MCM4
Target Synonym: 19G; AI325074; AU045576; CDC 21; CDC 54; CDC21; CDC21 homolog; CDC21; S. pombe; homolog of; CDC54; Cell division cycle 21; S. pombe; homolog of; DNA replication licensing factor MCM 4; DNA replication licensing factor MCM4; hCdc 21; hCdc21; Homolog of S. pombe cell devision cycle 21; KIAA4003; mcdc21; MCM 4; MCM 4 minichromosome maintenance deficient 4; mcm4; MCM4 minichromosome maintenance deficient 4; MCM4 minichromosome maintenance deficient 4; mitotin (S. cerevisiae); MCM4; Mcmd4; MGC33310; Minichromosome maintenance 4; Minichromosome maintenance complex component 4; Minichromosome maintenance deficient (S. cerevisiae) 4; Minichromosome maintenance deficient 4; Minichromosome maintenance deficient 4 homolog (S. cerevisiae); Minichromosome maintenance; S. cerevisiae; homolog of; 4; mKIAA4003; NKCD; NKGCD; P1 CDC21; P1-CDC21; P1CDC21
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: WB, IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P33991
Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Concentration: 0.3 mg/mL
Immunogen: Synthetic peptide of human MCM4
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:50-1:200
Calculated MW: 97kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only