MCM4 rabbit pAb - ES6208

MCM4 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6208-50, ES6208-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcri

Alternate Name: MCM4; CDC21; DNA replication licensing factor MCM4; CDC21 homolog; P1-CDC21

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human MCM4. AA range:20-69

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 96kD

Human Gene ID: 4173

Human SWISS Prot NO: P33991

Subcellular Location: Nucleus. Chromosome. Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.

Research Use Only