Product Description

MCM8 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11181-20, BT-AP11181-50, BT-AP11181-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Research Areas: Epigenetics and nuclear signaling

Target Protein: MCM8

Applications: WB, ELISA

Reactivity: Human, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: DNA helicase MCM8

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9UJA3; Mouse: Q9CWV1; Rat: D3ZVK1

Synonyms: DNA helicase MCM8;EC 3.6.4.12;Minichromosome maintenance 8

GeneID: Human: 84515

Research Use Only