MCOLN2 Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS67768-50, BS67768-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: The mucolipins are a family of cation channel proteins designated mucolipin 1, mucolipin 2 and mucolipin 3. Mucolipin 2 is a lysosomal protein that interacts with the ARF6-associated pathway through co-localization with the cargo proteins CD59 and MHC1. These interactions are thought to traffic and regulate the sorting of certain glycosyl-anchored proteins in the ARF6-associated pathway. Mucolipin 2 is found primarily in the plasma membrane, but is also expressed in intracellμlar vesicles, tubμlar structures and B lymphocytes. Mucolipin 2 expression in B lymphocytes and its association with Bruton’s tyrosine kinase suggests a possible role in B lymphocyte development. Additionally, defects in the mucolipin 2 gene may be associated with certain neurosensory disorders, as well as swelling of late endosomes and lysosomes. Category: Primary Antibody Reactivity: Human, Rat Host: Rabbit Applications: WB Alternate Names: Mucolipin-2 Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: Recombinant protein corresponding to human MCOLN2. The exact sequence is proprietary. Dilution: WB (1/500 - 1/1000) Purification: The antibody was purified by immunogen affinity chromatography. Specificity: Recognizes endogenous levels of MCOLN2 protein. Molecular Weight: ~ 80 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q8IZK6 Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Research Use Only