MCOLN2 Polyclonal Antibody Catalogue Numbers: BS67768-50, BS67768-100 Sizes: 50µl, 100µl Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Swiss-Prot: Q8IZK6 Host: Rabbit Reactivity: Human, Rat Applications: WB All Applications: WB (1/500 - 1/1000) Background: The mucolipins are a family of cation channel proteins designated mucolipin 1, mucolipin 2 and mucolipin 3. Mucolipin 2 is a lysosomal protein that interacts with the ARF6-associated pathway through co-localization with the cargo proteins CD59 and MHC1. These interactions are thought to traffic and regulate the sorting of certain glycosyl-anchored proteins in the ARF6-associated pathway. Mucolipin 2 is found primarily in the plasma membrane, but is also expressed in intracellular vesicles, tubular structures and B lymphocytes. Mucolipin 2 expression in B lymphocytes and its association with Bruton’s tyrosine kinase suggests a possible role in B lymphocyte development. Additionally, defects in the mucolipin 2 gene may be associated with certain neurosensory disorders, as well as swelling of late endosomes and lysosomes. Purification and Purity: The antibody was purified by immunogen affinity chromatography. Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: Recognizes endogenous levels of MCOLN2 protein. Extra Notes: Western blot analysis of MCOLN2 expression in THP1 (A) whole cell lysates. Bioworld Molecular Weight: ~ 80 kDa Note: For research use only, not for use in diagnostic procedure. Alternative Name: Mucolipin-2 Immunogen: Recombinant protein corresponding to human MCOLN2. The exact sequence is proprietary. Conjugate: Unconjugated Modification: Unmodified