MDA5 Phospho-ser828 Rabbit Polyclonal Antibody - RA36908

MDA5 Phospho-ser828 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36908-50, RA36908-100

Citations, Manuals and MSDS Available upon request.

Background: interferon induced with helicase C domain 1 (IFIH1) Homo sapiens DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-depend

Condition: Liquid in PBS containing 50% glycerol, and 0.224% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 64135

SWISS: Q9BYX4

Source: Rabbit

Research Use Only