MDM2 (phospho Ser186/S188) Polyclonal Antibody - RA27115

MDM2 (phospho Ser186/S188) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27115-50, RA27115-100

Citations, Manuals and MSDS Available upon request.

Background: MDM2 proto-oncogene (MDM2) Homo sapiens This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000 Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Alternative Names: MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2

Applications: IF/ICC; WB; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 4193

SWISS: Q00987

Source: Rabbit

Research Use Only