Product Description

MDMX Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65982-50, BS65982-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecμles of zinc mediates the heterooligomerization with MDM2.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep

Host: Rabbit

Applications: WB

Alternate Names: Double minute 4, Double minute 4 human homolog of p53 binding protein, Double minute 4 protein, HDMX, MDM 4, Mdm2 like p53 binding protein, Mdm2-like p53-binding protein, MDM4, Mdm4 p53 binding protein homolog mouse, Mdm4 protein, MDM4 related protein 1, Mdm4 transformed 3T3 cell double minute 4, Mdm4 transformed 3T3 cell double minute 4 p53 binding protein, Mdm4 transformed 3T3 cell double minute 4 p53 binding protein mouse, MDM4_HUMAN, Mdmx protein, Mouse double minute 4 homolog, Mouse double minute 4 human homolog of, Mouse double minute 4 human homolog of p53 binding protein, MRP 1, MRP1, p53 binding protein, p53 BINDING PROTEIN MDM4, p53-BINDING PROTEIN MDM4, Protein Mdm4, Protein Mdmx.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human MDMX:301-400/490

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: MDMX Polyclonal Antibody detects endogenous levels of MDMX protein.

Molecular Weight: 55 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15151

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only