MDR3 Monoclonal Antibody-MB66926

MDR3 Monoclonal Antibody

Catalogue Numbers: MB66926-50, MB66926-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P21439

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/1000 - 1/2000)

Background: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts
Plays a role in the recruitment of phosphatidylcholine , phosphatidylethanolamine and sphingomyelin molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes .Required for proper phospholipid bile formation.Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner.Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane .In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts .Does not confer multidrug resistance .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of MDR3 protein.

Extra Notes: Western blot analysis of MDR3 expression in MCF7 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: MDR3; PGY3; Multidrug resistance protein 3; ATP-binding cassette sub-family B member 4; P-glycoprotein 3

Immunogen: Recombinant fusion protein of human MDR3. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified