Product Description

MeCP2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21147-50, RA21147-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: methyl-CpG binding protein 2 (MECP2) Homo sapiens DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Clonality: Polyclonal

Dilution: WB: 1:2000

Molecular Weight: 53

Protein Molecular Weight (kDa): 53

Storage: -20°C/1 year

Human Gene ID: 4204

Human SwissProt Number: P51608

Condition: PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Research Use Only