MED28 rabbit pAb - ES9789

MED28 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES9789-50, ES9789-100

Citations, Manuals and MSDS Available upon request.

Background: function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways., induction:Up-regulated by endothelial cells when exposed to tumor conditional media., similarity:Belongs to the Mediator complex subunit 28 family., subcellular location:According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated., subunit:Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Forms a ternary complex with NF2/merlin and GRB2. Binds to actin., tissue specificity:Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human protein . at AA range: 20-100

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 19kD

Human Gene ID: 80306

Human SWISS Prot NO: Q9H204

Subcellular Location: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.

Research Use Only