Product Description

MEF-2 (phospho-T312) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4120-50, BS4120-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The myocyte enhancer factor-2 (MEF-2) family of transcription factors associated with co-repessors or co-activators to regμlate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regμlation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regμlate muscle gene expression.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IP

Alternate Names: Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1, MEF2A, MEF2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human MEF-2 around the phosphorylation site of Threonine 312.

Dilution: IHC: 1:50~1:200
IP: 1:10~1:100

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-MEF-2 (T312) polyclonal antibody detects endogenous levels of MEF-2 protein only when phosphorylated at Thr312

Molecular Weight: ~ 55 kDa

Pathway: Signaling Pathways Activating p38 MAP Kinase, Examples of Crosstalk Between Post-translational Modifications,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q02078

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only