Product Description

MEF2A Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11202-50, MB11202-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q02078

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 55 kDa; Observed MW: 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of MEF2A in mouse brain, rat brain lysates using MEF2A antibody., Western blot analysis of MEF2A in 293T, Jurkat lysates using MEF2A antibody.

Alternative Name: mef2; ADCAD1; RSRFC4; RSRFC9

Immunogen: A synthetic peptide of human MEF2A

Conjugate: Unconjugated

Modification: Unmodified