Product Description

MEK-7  (phospho-S271)  Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4906-50, BS4906-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MKK7 is a MAP kinase kinase that serves as a specific activator of the SAPK/JNK pathway. MKK7 is strongly activated by TNF-α, as well as other environmental stresses, whereas SEK1/MKK4, which activates both p38 and SAPK/JNK pathways, is not activated by TNF-α. Sequence alignment of the activation loop of the MAP kinase kinase family members indicates that Ser271 and Thr275 are potential phosphorylation sites that are crucial for the kinase acivity.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Mitogen Activated Protein Kinase kinase 7, c-Jun N-terminal kinase kinase 2, JNK activating kinase 2, Jnkk 2, Jnkk2, MAP2K7, MAPKK-7, MKK 7, MKK-7, PRKMK 7, PRKMK7, Sek-2, Dual specificity mitogen activated protein kinase kinase 7, JNK kinase 2, Jnkk

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human MEK-7 around the phosphorylation site of Serine 271

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MEK-7 (phospho-S271) polyclonal antibody detects endogenous levels of MEK-7 protein only when phosphorylated at Ser271.

Molecular Weight: ~ 48 kDa

Pathway: SAPK JNK Signaling Cascades,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14733

Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Research Use Only