Product Description

MEKKK6 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62283-50, BS62283-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Serine/threonine kinase which acts as a negative regμlator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimμlation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimμlation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regμlation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Misshapen-like kinase 1, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, Misshapen/NIK-related kinase, Mitogen-activated protein kinase kinase kinase kinase 6, MINK1, B55, MAP4K6, MINK, YSK2, ZC3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human MEKKK6.

Dilution: WB:1:500~1:1000 IHC:1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MEKKK6 polyclonal antibody detects endogenous levels of MEKKK6 protein.

Molecular Weight: ~ 150 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8N4C8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only