Product Description

MEL-1B-R (V39) Polyclonal Antibody

Catalogue Numbers:BS2817-50, BS2817-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P49286

Host: Rabbit

Reactivity: Human

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the superfamily of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. The melatonin receptors are activated by the hormone melatonin (Mel), which is secreted by the pineal gland at night as part of the circadian clock. MEL-1A-R, a 37 kD protein, is thought to be involved in pacing the biological clock. However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin. MEL-1B-R is an integral membrane protein expressed in retina and less in brain and hippocampus. Functional studies of NIH/3T3 cells stably expressing the MEL-1B-R melatonin receptor indicate that it is coupled to inhibition of adenylyl cyclase.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~ 40 kDa

Specificity: MEL-1B-R (V39) polyclonal antibody detects endogenous levels of MEL-1B-R protein.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: Melatonin receptor type 1B; Mel-1B-R; Mel1b receptor; MTNR1B

Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human MEL-1B-R.

Conjugate: Unconjugated

Modification: Unmodified